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RESEARCH PRODUCT
Tuning the selectivity of molecularly imprinted polymer extraction of arylcyclohexylamines: From class-selective to specific
Sergio ArmentaA. Sorribes-sorianoF.a. Esteve TurrillasJosé Manuel Herrero-martínezsubject
AnalyteArylcyclohexylamineBulk polymerizationSurface PropertiesIon-mobility spectrometry02 engineering and technology01 natural sciencesBiochemistryPolymerizationAnalytical ChemistryMolecularly Imprinted PolymersIon Mobility SpectrometrymedicineEnvironmental ChemistryParticle SizeSpectroscopyDetection limitCyclohexylaminesChromatographyMolecular StructureChemistry010401 analytical chemistryMolecularly imprinted polymer021001 nanoscience & nanotechnology0104 chemical sciencesSolvent0210 nano-technologySelectivitymedicine.drugdescription
Abstract A molecularly imprinted polymer (MIP) has been prepared in presence of 3-hydroxy phencyclidine (3-OH PCP) as template by bulk polymerization using N,N-dimethylformamide, as porogenic solvent, for the selective solid-phase extraction (SPE) of arylcyclohexylamines from oral fluids. Experimental variables of the extraction procedure have been studied in order to increase both, extraction recovery of 3-OH PCP, used as model analyte, and imprinting factor. By modifying the composition of the washing solvent, the selectivity of the MIP extraction procedure can be tuned, moving from an arylcyclohexylamine selective method to a 3-OH PCP specific method. The applicability of the synthesized MIP was evaluated by the analysis of oral fluids spiked with 3-OH PCP at different concentration levels, extracted using both recommended SPE procedures and analyzed by ion mobility spectrometry. Recovery values ranging from 70 to 101% and a limit of detection of 15 μg L−1 were obtained.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-03-25 | Analytica Chimica Acta |