6533b82efe1ef96bd12925ef
RESEARCH PRODUCT
Synthesis of azamacrocycles via a Mitsunobu reaction
Jari HovinenReijo Sillanpääsubject
chemistry.chemical_compoundChemistryDiisopropyl azodicarboxylateOrganic ChemistryDrug DiscoveryPyridineDiethylenetriamineOrganic chemistryMitsunobu reactionTriphenylphosphineBiochemistrydescription
Reaction of pernosylated diethylenetriamine and 2-substituted propane-1,3-diols in dry THF in the presence of triphenylphosphine and diisopropyl azodicarboxylate gives the corresponding protected 9-substituted 1,4,7-triazacyclodecanes. The Mitsunobu reaction was also used in the preparation of 3-substituted 1,5,9-triazacyclododecanes and macrocyclic pyridine derivatives.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-06-01 | Tetrahedron Letters |