6533b82efe1ef96bd12927c5
RESEARCH PRODUCT
Cytotoxicity of abietane diterpenoids from Salvia multicaulis towards multidrug-resistant cancer cells.
Ahmed R. HamedShinji OhtaPaul W. ParéAli M. El-halawanyThomas A. EfferthMohamed-elamir F. HegazySara AbdelfatahEssam Abdel-sattarTaha A. Hussiensubject
Phytochemicals01 natural scienceschemistry.chemical_compoundCell Line TumorDrug DiscoverymedicineCytotoxic T cellHumansSalviaCytotoxicityAbietanePharmacologybiologyMolecular Structure010405 organic chemistryChemistryCancerGeneral MedicinePlant Components Aerialbiology.organism_classificationmedicine.diseaseDrug Resistance Multiple0104 chemical sciencesMultiple drug resistance010404 medicinal & biomolecular chemistryCell cultureDrug Resistance NeoplasmCancer cellAbietanesCancer researchEgyptSalvia multicaulisdescription
Diterpenoids salvimulticanol (1) and salvimulticaoic acid (2) together with known diterpenoid (3-6) were isolated from Salvia multicaulis. Structures were elucidated by spectroscopic techniques including HRESIMS as well as 1D-, and 2D-NMR. In-vitro cytotoxicity was assayed against human cancer cell lines. As several metabolites exhibited activity against drug-resistance lines, compounds were screened against a panel of human drug-sensitive and multidrug-resistant cancer lines. A proposed biosynthetic pathway for these new diterpenoids (1-2) as well as the cytotoxic structure-activity relationship of all identified compounds were discussed. Compound 1 and 6 showed the most potent cytotoxicity with IC50 11.58 and 4.13 towards leukemia cell lines CCRF-CEM and CEM-ADR5000, respectively.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-10-01 | Fitoterapia |