MPLA-coated hepatitis B virus surface antigen (HBsAg) nanocapsules induce vigorous T cell responses in cord blood derived human T cells.

6533b82efe1ef96bd12927df

RESEARCH PRODUCT

MPLA-coated hepatitis B virus surface antigen (HBsAg) nanocapsules induce vigorous T cell responses in cord blood derived human T cells.

Frederik R. Wurm Keti Piradashvili Michael Fichter Anette Pietrzak-nguyen Leah Pretsch Stephan Gehring Katharina Landfester Fred Zepp

subject

0301 basic medicine HBsAg Hepatitis B virus T cell T-Lymphocytes Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous)Bioengineering medicine.disease_cause Virus 03 medical and health sciences 0302 clinical medicine Immune system Nanocapsules medicine Humans General Materials Science Hepatitis B Vaccines Hepatitis B virus Liver infection Hepatitis B Surface Antigens business.industry Dendritic Cells Hepatitis B medicine.disease Fetal Blood Hepatitis B Virology 030104 developmental biology medicine.anatomical_structure Immunology Antigens Surface Molecular Medicine business CD80 030215 immunology

description

Chronic hepatitis B virus (HBV) infection is the most prevalent serious liver infection in the world. A frequent route of infection represents mother-to-child transmission. Efficient control of HBV replication depends on antigen-specific cellular immune response mediated by dendritic cells (DCs). Aim of the present study was to evaluate optimized adjuvant combinations, efficiently maturing monocyte-derived neonatal and adult dendritic cells (moDCs). In addition, the potential of polymeric HBsAg-nanocapsules (HBsAg-NCs) was investigated regarding up-take by moDCs and the subsequent induction of specific T cell responses in a human co-culture model. Simultaneous stimulation of moDCs with MPLA and IFNγ induced up-regulation of CD80 and HLA-DR along with vigorous secretion of IL-12p70. MPLA-coating of HBsAg-NCs promoted NCs-uptake by moDCs. Finally, MPLA-HBsAg-NCs-pulsed moDCs with IFNγ increased T cell proliferation and induced antigen-specific IFNγ release by T cells. The herein presented vaccine approach provides a rational for neonatal and therapeutic immunization strategies against HBV.

year	journal	country	edition	language
2016-02-17	Nanomedicine : nanotechnology, biology, and medicine

10.1016/j.nano.2016.07.010 https://pubmed.ncbi.nlm.nih.gov/27516081

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