New pharmacotherapeutic approaches in targeting neurodegenerative processes

6533b82efe1ef96bd1292ccb

RESEARCH PRODUCT

New pharmacotherapeutic approaches in targeting neurodegenerative processes

Karīna Narbute

subject

Pharmacology Farmācija Medicīna un farmācija Basic Medical Science Medicīna

description

Visizplatītākās neirodeģeneratīvās un joprojām neizārstējamās slimības ir sporādiskās formas Alcheimera slimība (sAD) un Pārkinsona slimība (PD). Tām ir kopīgi etiopatoģenētiski cēloņi, kas ar laiku izraisa kognitīvo spēju samazināšanos. Terapija jāmērķē uz tiem patoloģiskajiem procesiem, kas ir kopīgi un raksturīgi gan sAD, gan PD to agrīnajās stadijās. Darbā esam izvēlējušies inovatīvu pieeju, izmantojot ekstracelulārās vezīkulas (EVs) un antihiperglikēmisko preparātu metformīnu. Iegūtie dati pirmoreiz parāda EVs un metformīna neiroprotektīvās un regulējošās īpašības sAD un PD modeļdzīvniekos, kas norāda uz šo vielu perspektivitāti šo slimību agrīno stadiju patoloģisko procesu savlaicīgā apturēšanā. Atslēgas vārdi: Alcheimera slimība; Pārkinsona slimība; STZ; 6-OHDA; ekstracelulārās vezīkulas; metformīns; gaita; mācīšanās/atmiņa; proteīnu ekspresija.

year	journal	country	edition	language
2020-01-01

https://dspace.lu.lv/dspace/handle/7/52871

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