6533b82efe1ef96bd12930b3

RESEARCH PRODUCT

Prognostic Relevance of CCN3 in Bone Sarcomas

José Antonio López-guerreroKatia ScotlandiPiero PicciBernard PerbalMassimo SerraNoureddine LazarMonia ZuntiniAntonio Llombart-boschDiana Zambelli

subject

integumentary systembusiness.industryMatricellular proteinEwing's sarcomaCcn familyBone Sarcomamedicine.diseaseMetastasismedicineCancer researchOsteosarcomaBone formationSarcomabusiness

description

Osteosarcomas and Ewing’s sarcoma (EWS) are aggressive malignant bone tumors. In both cases, prognostic markers are lacking. Presently, only clinical features are widely accepted as prognostic indicators. In this study we assessed the prognostic value of CCN3 (Nov), a matricellular protein that belong to the CCN family of regulatory proteins, whose members were shown to play crucial roles in bone formation. In osteosarcomas, CCN3 expression levels represent a useful tool to early identification of patients with different prognosis. In both osteosarcomas and Ewing’s sarcomas, the expression of a full length CCN3 protein was associated to a worse prognostic and a higher risk to developing metastasis. In Ewing’s tumors, the expression of a CCN3 protein lacking the internal VWC module was associated with reduced tumorigenic potential and better outcome.

yearjournalcountryeditionlanguage
2010-01-01
https://doi.org/10.1007/978-90-481-3779-4_17