6533b82efe1ef96bd12931d9
RESEARCH PRODUCT
Antimicrobial activity of methylene blue and toluidine blue O covalently bound to a modified silicone polymer surface
Ivan P. ParkinStefano PerniClara PiccirilloJ. Gil-thomasJonathan PrattenMichael WilsonPolina Prokopovichsubject
chemistry.chemical_classificationRMAbsorption spectroscopybiologyGeneral ChemistryPolymerPhotochemistrybiology.organism_classificationCondensation reactionmedicine.disease_causeRSchemistry.chemical_compoundchemistryCovalent bondStaphylococcus epidermidisAmidePolymer chemistryMaterials ChemistrymedicineEscherichia coliMethylene bluedescription
Methylene Blue or Toluidine Blue O were covalently bound to an activated silicone polymer by means of an amide condensation reaction. UV-visible absorption spectra confirmed that the dye was surface bound. The new polymers with covalently attached dye display significant bactericidal activity against Escherichia coli and Staphylococcus epidermidis with a 99.999% reduction in viable bacteria after four minutes exposure to a low power laser.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 | Journal of Materials Chemistry |