6533b82efe1ef96bd129349f
RESEARCH PRODUCT
A Versatile and Convenient Method for the Functionalization of Porphyrins
Philippe RichardLydie MichaudetAmandine DidierValérie Baveux-chambenoîtBernard BoitrelDavid Ricardsubject
Cation bindingAtropisomerHemeproteinPorphyrinsChemistryEnzyme modelsOrganic ChemistryPorphyrinCombinatorial chemistry[ CHIM ] Chemical SciencesHeme proteinschemistry.chemical_compoundBenzoyl chlorideNucleophileReagentCationspolycyclic compounds[CHIM]Chemical SciencesOrganic chemistrySurface modificationPhysical and Theoretical ChemistryOxidoreductasesdescription
International audience; The condensation of 3-(chloromethyl)benzoyl chloride with different atropisomers of meso-(tetra-o-aminophenyl)porphyrin (TAPP), followed by the reaction of a series of nucleophilic reagents leads, among others, to precursors of biomimetic models of heme proteins such as cytochrome c oxidase (CcO). This synthesis can also be applied as an efficient two-step reaction to obtain highly functionalized porphyrin derivatives potentially useful for cation binding.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-05-01 |