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RESEARCH PRODUCT
Microwave-Assisted Synthesis of New Selenazole Derivatives with Antiproliferative Activity
Thomas EfferthVictor KueteLuminita Silaghi-dumitrescuValentin ZahariaAdriana IgnatLuiza Gainasubject
AzolesHL60Pharmaceutical ScienceAntineoplastic AgentsHL-60 CellsMicrowave assistedArticleLeukemia cell lineAnalytical Chemistrylcsh:QD241-441Inhibitory Concentration 50chemistry.chemical_compoundlcsh:Organic chemistryselenazole; microwave assisted synthesis; cytotoxicityCell Line TumorOrganoselenium CompoundsCarcinoma CellDrug DiscoveryHumansPhysical and Theoretical ChemistryMicrowavesCell ProliferationOrganic ChemistryselenazoleHCT116 CellsCondensation reactionCombinatorial chemistrychemistryChemistry (miscellaneous)Elemental analysisMicrowave heatingcytotoxicityMolecular Medicinemicrowave assisted synthesisdescription
New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, 1 H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-04-01 | Molecules |