6533b82efe1ef96bd1293aee

RESEARCH PRODUCT

Molecular Diagnostics: Innovative Technologies for Clinical and Translational Research

Alessandro PerezUmberto MalapelleMarta CastigliaFrancesco Pepe

subject

Clinical PracticeOncogene ActivationOncogenebusiness.industryCancer cellMedicineCancerTranslational researchTarget therapybusinessMolecular diagnosticsmedicine.diseaseBioinformatics

description

In recent years, cancer patients’ treatment has profoundly changed due to a better comprehension of the biological processes underlying tumor development and progression. Several tumors are defined as “oncogene addicted” meaning that they are strictly dependent on oncogene activation for their own survival. This discovery has indeed led the way to the development of target therapies that are able to specifically kill cancer cells sparing normal cells from toxicity. For these reasons, nowadays, treatment decision is strictly dependent on the molecular characterization of the tumor that can be achieved through different technologies. Within this chapter, we will discuss the main technologies that are used in clinical practice for molecular characterization of tumor samples.

yearjournalcountryeditionlanguage
2021-01-01
https://doi.org/10.1007/978-3-030-56051-5_8