6533b82efe1ef96bd1293bcc
RESEARCH PRODUCT
Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception
Felipe VilellaWanxin WangInmaculada MorenoStephen R. QuakeCarlos Simonsubject
Andrologymedicine.anatomical_structureSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CellmedicineEmbryoBiologyEndometriumGeneAsymptomatic carrierTMPRSS2Tropismdescription
AbstractWe investigated potential SARS-CoV-2 tropism in human endometrium by single-cell RNA-sequencing of viral entry-associated genes in healthy women. Percentages of endometrial cells expressing ACE2, TMPRSS2, CTSB, or CTSL were <2%, 12%, 80%, and 80%, respectively, with 0.7% of cells expressing all four genes. Our findings imply low efficiency of SARS-CoV-2 infection in the endometrium before embryo implantation, providing information to assess preconception risk in asymptomatic carriers.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-14 |