6533b82efe1ef96bd1293c82
RESEARCH PRODUCT
Chronic oral haloperidol and clozapine in rats: A behavioral evaluation.
Christoph HiemkeHarald WeigmannUlrich SchmittMarie Luise RaoViola FischerStefan ReussNorbert Dahmensubject
medicine.medical_specialtyDyskinesia Drug-InducedTime FactorsAdministration OralPharmacologyWeight GainOpen fieldRats Sprague-DawleyBlood serumOral administrationInternal medicinemedicineHaloperidolAnimalsHabituationHabituation PsychophysiologicClozapineBiological PsychiatryClozapineAnalysis of VarianceBehavior Animalbusiness.industryAntagonistRatsPsychiatry and Mental healthNeuropsychology and Physiological PsychologyEndocrinologyExploratory BehaviorHaloperidolFemaleAnalysis of variancebusinessLocomotionmedicine.drugAntipsychotic Agentsdescription
The present study evaluated chronic oral treatment of rats with haloperidol or clozapine. Drugs were given in the drinking water for a 23-day period . Rat behavior was analyzed once a week in an open field. Rats ingested either 1.7 mg/kg haloperidol or 40 mg/kg clozapine daily. Blood serum analysis revealed concentrations of 6 ng/ml for haloperidol and 22 ng/ml for clozapine at the end of the treatment. Haloperidol decreased overall activity from the onset of treatment. Clozapine showed similar effects only on the last test day. Control animals showed a slight habituation in exploration-related parameters. In conclusion, these results indicate that oral drug administration through the drinking water is a suitable mode of noninvasive chronic treatment that led to sufficiently high drug levels to induce specific pharmacological effects in rats.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-03-11 | Neuropsychobiology |