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RESEARCH PRODUCT

Pregnancy Outcome in Maternal Crigler-Najjar Syndrome Type II: A Case Report and Systematic Review of the Literature

A. PuhlE. SteinerC. SkalaN KohlschmidtS WirthV. PassuelloH. Koelbl

subject

AdultMaleEmbryologyPediatricsmedicine.medical_specialtyBilirubinCrigler–Najjar syndromeDiseasechemistry.chemical_compoundPregnancymedicineHumansRadiology Nuclear Medicine and imagingNeonatologyHearing DisordersKernicterusCrigler-Najjar SyndromePregnancyFetusbusiness.industryInfant NewbornPregnancy OutcomeInfantObstetrics and GynecologyBilirubinGeneral Medicinemedicine.diseaseSurgeryPregnancy ComplicationschemistryPhenobarbitalPediatrics Perinatology and Child HealthGestationFemalePhenobarbitalbusinessmedicine.drug

description

<i>Objective:</i> To report a case of maternal Crigler-Najjar syndrome (CNS) type II in pregnancy, systematically review the literature for similar case reports, and to evaluate whether pregnancy is safe in patients with the disease. Data sources included the PubMed and uptodate databases. <i>Results:</i> A 37-year-old mother with CNS type II was treated with phenobarbital during her pregnancy and her bilirubin levels were monitored. Her newborn had mild direct hyperbilirubinemia, did not require any treatment and his postnatal follow-up showed normal growth and development as well as normal hearing. <i>Conclusion:</i> CNS type II is rare, and only a few pregnancies with this condition have been reported. Maternal treatment with phenobarbital lowers the unconjugated bilirubin and avoids fetal and newborn sequelae.

yearjournalcountryeditionlanguage
2008-04-16Fetal Diagnosis and Therapy
https://doi.org/10.1159/000238122