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RESEARCH PRODUCT

Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors — Results from a systematic review and meta-analysis of randomized controlled trials

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Introduction: Numerous studies have suggested that oral supplementation with resveratrol exerts cardioprotective effects, but evidence of the effects on C-reactive protein (CRP) plasma levels and other cardiovascular (CV) risk factors is inconclusive. Therefore, we performed a meta-analysis to evaluate the efficacy of resveratrol supplementation on plasma CRP concentrations and selected predictors of CV risk. Methods:The searchincludedPUBMED,Cochrane Library,Web ofScience,Scopus,andEMBASE(up toAugust31, 2014) to identify RCTs investigating the effects of resveratrol supplementation on selected CV risk factors. Quantitative data synthesis was performed using a random-effects model, with weighted mean difference (WMD) and 95% confidence intervals (CI) as summary statistics. Results: Meta-analysisof data from10RCTs(11 treatment arms) didnot supporta significant effectof resveratrol supplementation in altering plasma CRP concentrations (WMD: −0.144 mg/L, 95% CI: −0.968–0.680, p = 0.731). Resveratrol supplementation was not found to alter plasma levels of total cholesterol (WMD: 1.49 mg/dL, 95% CI: −14.96–17.93, p = 0.859), low density lipoprotein cholesterol (WMD: −0.31 mg/dL, 95% CI: −9.57–8.95, p = 0.948), triglycerides (WMD: 2.67 mg/dL, 95% CI: −28.34–33.67, p = 0.866), and glucose (WMD: 1.28 mg/dL, 95% CI: −5.28–7.84, p = 0.703). It also slightly reduced high density lipoprotein cholesterol concentrations (WMD: −4.18 mg/dL, 95% CI: −6.54 to −1.82, p = 0.001). Likewise, no significant effect was observed on systolic (WMD: 0.82 mm Hg, 95% CI: −8.86–10.50, p = 0.868) and diastolic blood pressure (WMD: 1.72 mm Hg, 95% CI: −6.29–9.73, p =0 .674). Conclusions: This meta-analysis of available RCTs does not suggest any benefit of resveratrol supplementation on CV risk factors. Larger, well-designed trials are necessary to confirm these results.