6533b82efe1ef96bd1293e94

RESEARCH PRODUCT

The Effect of Nitrazepam on Manual Skill, Grip Strength, and Reaction Time with Special Reference to Subjective Evaluation of Effects on Sleep

Ulla LahtinenAntti LahtinenPentti Pekkola

subject

AdultInjury controlNitrazepammedicine.drug_classAccident preventionPoison controlMotor ActivityToxicologybehavioral disciplines and activitiesHypnoticGrip strengthReaction TimemedicineHumansIngestionNitrazepamPharmacologyPsychomotor learningClinical Trials as Topicbusiness.industryMotor SkillsAnesthesiaDrug EvaluationFemaleSleepbusinessMuscle Contractionmedicine.drug

description

The effects of 5 and 10 mg oral nitrazepam doses on manual skills, grip strength, and reaction time 8 hours after ingestion of the drugs were studied in 34 healthy female volunteers aged 19-22 years. 5 mg nitrazepam caused a slight but insignificant decrease in psychomotor skills. With 10 mg psychomotor skills were influenced significantly. Grip strength and reaction time were not influenced either by the 5 or 10 mg doses. The investigators corroborate the value of the established effects of nitrazepam as a hypnotic, but recommend that caution should be excercised in prescribing the drug as a hypnotic (especially in doses exceeding 5 mg) to work-aged subjects as there is a risk of significant effect on the psychomotor skills. Furthermore, the drug may cause fatigue. Language: en

yearjournalcountryeditionlanguage
1978-02-01Acta Pharmacologica et Toxicologica
https://doi.org/10.1111/j.1600-0773.1978.tb02180.x