6533b82efe1ef96bd1293eb8

RESEARCH PRODUCT

NANOPARTICLES BASED ON NOVEL AMPHIPHILIC POLYASPARTAMIDE COPOLYMERS

Gennara CavallaroMaria Chiara OgnibeneMaria Luisa BondìMaria Pia CasalettoGirolamo TeresiEmanuela Fabiola Craparo

subject

Materials scienceALPHABETA-poly-(N-2-hydroxyethyl)-DL-aspartamide (PHEA) poly(lactic acid) (PLA) poly(ethylene glycol) (PEG) graft copolymers nanoparticlesSize-exclusion chromatographytechnology industry and agricultureNanoparticleBioengineeringGeneral Chemistrymacromolecular substancesCondensed Matter PhysicsAtomic and Molecular Physics and Opticschemistry.chemical_compoundX-ray photoelectron spectroscopychemistrystomatognathic systemSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoModeling and SimulationAmphiphilePolymer chemistryPEG ratioCopolymerZeta potentialGeneral Materials ScienceDerivatization

description

In this article, the synthesis of two amphiphilic polyaspartamide copolymers, useful to obtain polymeric nanoparticles without using surfactants or stabilizing agents, is described. These copolymers were obtained starting from α,β-poly-(N-2-hydroxyethyl)-dl-aspartamide (PHEA) by following a novel synthetic strategy. In particular, PHEA and its pegylated derivative (PHEA-PEG2000) were functionalized with poly(lactic acid) (PLA) through 1,1′-carbonyldiimidazole (CDI) activation to obtain PHEA–PLA and PHEA-PEG2000–PLA graft copolymers, respectively. These copolymers were properly purified and characterized by 1H-NMR, FT-IR, and Size Exclusion Chromatography (SEC) analyses, which confirmed that derivatization reactions occurred. Nanoparticles were obtained from PHEA–PLA and PHEA-PEG2000–PLA graft copolymers by using the high pressure homogenization-solvent evaporation method, avoiding the use of surfactants or stabilizing agents. Polymeric nanoparticles were characterized by dimensional analysis, before and after freeze-drying process, and Scanning Electron Microscopy (SEM). Zeta potential measurements and X-ray Photoelectron Spectroscopy (XPS) analysis demonstrated the presence of PEG and/or PHEA onto the PHEA-PEG2000–PLA and PHEA–PLA nanoparticle surface, respectively.

yearjournalcountryeditionlanguage
2010-01-12
http://hdl.handle.net/10447/51464