6533b82efe1ef96bd1293f27

RESEARCH PRODUCT

Inhibition of Gill Na+,K+-ATPase Activity in the Eel,Anguilla anguilla,by Fenitrothion

Encarna SanchoEnrique J. AndreuM.d. Ferrando

subject

GillsInsecticidesanimal structuresHealth Toxicology and MutagenesisATPaseFenitrothionchemistry.chemical_compoundAnimal scienceAnguillidaeAnimalsNa k atpase activitychemistry.chemical_classificationDose-Response Relationship DrugbiologyPublic Health Environmental and Occupational HealthFenitrothionGeneral MedicineAnatomyPesticideAnguillabiology.organism_classificationPollutionDose–response relationshipEnzymechemistryToxicitybiology.proteinEnvironmental PollutantsSodium-Potassium-Exchanging ATPase

description

European eels (Anguilla anguilla) were exposed to sublethal fenitrothion concentrations (0.02 and 0.04 mg/liter) in a continuous flow-through system for 4 days. Gill Mg2+- and Na+,K+-ATPase activities were evaluated after 2, 8, 12, 24, 32, 48, 56, 72, and 96 h of pesticide exposure. Results indicated that ATPase activity in gill tissue decreased as concentration of fenitrothion increased. Pesticide induced significant inhibitory effects on the Na+, K+-ATPase activity of A. anguilla, ranging from >56% inhibition at a sublethal concentration of 0.02 ppm to >73% inhibition at a sublethal concentration of 0.04 ppm. Eels were exposed to both fenitrothion concentrations for 96 h and then allowed a period of recovery in pesticide-free water. Samples were removed at 8, 12, 24, 48, 72, 96, 144, and 192 h and eel gill ATPase activity was evaluated. Following 1 week of recovery, the Na+,K+-ATPase activity for those animals previously exposed to 0.04 ppm fenitrothion was still different from that of the controls.

yearjournalcountryeditionlanguage
1998-02-14Ecotoxicology and Environmental Safety
https://doi.org/10.1006/eesa.1997.1573