6533b82efe1ef96bd1294478

RESEARCH PRODUCT

Regio- and stereoselective oxyfunctionalization at C-1 and C-5 in sesquiterpene guaianolides

Begoña GarcíaGonzalo BlayVictoria BarguesJ. R. PedroLuz Cardona

subject

Hydroxylationchemistry.chemical_compoundAllylic rearrangementchemistryStereochemistryOrganic ChemistryDrug DiscoveryOrganic chemistryStereoselectivitySesquiterpeneBiochemistry

description

Abstract The regio- and stereoselective functionalization at C-1 and C-5 positions in a guaiane skeleton by allylic hydroxylation are described. The stereochemistry of the resulting compounds are identical to those of the majority of natural 1- and 5-hydroxy-guaianolides.

https://doi.org/10.1016/s0040-4020(97)10392-1