Determination of Anticonvulsant Drugs in Pharmaceutical Preparations by Micellar Liquid Chromatography

6533b82efe1ef96bd129454b

RESEARCH PRODUCT

Determination of Anticonvulsant Drugs in Pharmaceutical Preparations by Micellar Liquid Chromatography

Salvador Sagrado M.j. Medina-hernández M. F. Cholbi‐cholbi Rosa María Villanueva-camañas J.j. Martínez-pla

subject

Chromatography Chemistry medicine.medical_treatment Clinical Biochemistry technology industry and agriculture Pharmaceutical Science Biochemistry Dosage form Analytical Chemistry Chlordiazepoxide Solvent Ethosuximide Anticonvulsant Micellar liquid chromatography Micellar solutions medicine lipids (amino acids peptides and proteins)Sample preparation medicine.drug

description

A micellar liquid chromatographic method for quality control of pharmaceutical preparations (capsules, pills, tablets, injections, drops, and suppositories) containing the anticonvulsant drugs acetazolamide, carbamacepine, chlordiazepoxide, diazepam, ethosuximide, phenytoin, phenobarbital, and zopiclone has been developed. This methodology involves the use of micellar solutions of cetyltrimethylammonium bromide (CTAB) as mobile phases and UV detection. The proposed approach is rapid and reproducible. Sample preparation only requires dissolution with micellar solvent and adequate dilution with the mobile phase before injection into the chromatographic system.

year	journal	country	edition	language
2004-01-01	Journal of Liquid Chromatography & Related Technologies

https://doi.org/10.1081/jlc-120027092

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