6533b82ffe1ef96bd1294662
RESEARCH PRODUCT
Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice.
Carmen ManzanedoMaría A. AguilarJosé MiñarroMarta Rodríguez-ariassubject
Malemedicine.medical_specialtyConditioning ClassicalPharmacologyChoice BehaviorReceptors DopamineBehavioral Neurosciencechemistry.chemical_compoundMiceDopamineInternal medicineOrientationpolycyclic compoundsmedicineHaloperidolAvoidance LearningAnimalsRacloprideSCH-23390MotivationDose-Response Relationship DrugMorphineChemistryAntagonistBrainConditioned place preferenceEndocrinologyDopamine receptorMorphineDopamine Antagonistsmedicine.drugdescription
The effects of dopamine (DA) antagonists with different selectivity for the DA receptors (SCH 23390, 0.5, 0.25, 0.125 mg/kg; haloperidol, 0.2, 0.1 mg/kg; raclopride, 1.2, 0.6, 0.3 mg/kg; risperidone, 0.4, 0.2, 0.1 mg/kg; U-99194A maleate, 40, 20 mg/kg; clozapine, 2.5, 1.25, 0.625 mg/kg) on the acquisition of place conditioning and morphine-induced conditioned place preference (CPP) were explored in male mice. Morphine (40 mg/kg) produced CPP while SCH 23390, haloperidol and clozapine (highest dose) and risperidone (lowest dose) produced conditioned place aversion (CPA). Raclopride and U-99194A maleate did not produce CPP or CPA. Morphine-induced CPP was reversed by the administration of SCH 23390 and risperidone (all doses), haloperidol (highest dose) and raclopride and clozapine (intermediate and lowest doses). U-99194A maleate did not reverse morphine-induced CPP. These results suggest that the conditioned rewarding effects of morphine are mediated by the different subtypes of DA receptors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-06-01 | Behavioural brain research |