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RESEARCH PRODUCT
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study
Fernando Fernández-arandaFernando Fernández-arandaDolores CorellaDolores CorellaJosé LapetraPilar MatíaAurora Bueno-cavanillasAurora Bueno-cavanillasJulia WärnbergManoli Garcia-de-la-heraXavier PintóPilar Buil-cosialesPilar Buil-cosialesNúria Mallorqui-bagueAina YañezEmilio RosEmilio RosAndrés Díaz-lópezAndrés Díaz-lópezItziar AbeteItziar AbeteJ. Alfredo MartínezJ. Alfredo MartínezMaría Lozano-madridJosep VidalJesús VioqueSusana Jiménez-murciaSusana Jiménez-murciaOlga CastañerJosé J. GaforioJosé J. GaforioClotilde VázquezMiguel Ruiz-canelaMiguel Ruiz-canelaRamon EstruchRamon EstruchDora RomagueraRafael De La TorreRafael De La TorreRocío BarragánRocío BarragánÁNgel M. Alonso-gómezJosep A. TurJosep A. TurJordi Salas-salvadóJordi Salas-salvadóFrancisco J. TinahonesMònica BullóMònica BullóEstefanía ToledoEstefanía ToledoAntonio Garcia-riosAntonio Garcia-riosAida Cuenca RoyoLluis Serra-majemLluis Serra-majemLidia DaimielVicente MartinVicente MartínJose Lopez-mirandaJose Lopez-mirandaMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezRoser Granerosubject
MaleCross-sectional studyhumanosType 2 diabetesOverweightPersones gransBody Mass Index0302 clinical medicineOlder people diseasesMedicine030212 general & internal medicineDiabetes Treatment AdherenceCognitive declineMalalties de les persones gransmediana edad2. Zero hungerMetabolic SyndromeancianoMultidisciplinaryDiabetisCognitive ageingQDiabetesRType 2 diabetesMiddle Aged3. Good healthNeurologydiabetes mellitusMedicineObesitatFemalemedicine.symptomPREDIMEDmedicine.medical_specialtyMedicinaScienceArticle03 medical and health sciencesOlder populationDiabetes mellitusInternal medicineApnoeaHumansCognitive DysfunctionObesityobesidadAgedGlycated Hemoglobinbusiness.industryíndice de masa corporalBaseline Cross-sectional AnalysisCognitive neuroscienceCognitive Function PerformanceOverweightmedicine.diseaseObesityCross-Sectional StudiesDiabetes Mellitus Type 2StudyMetabolic syndromeOlder peoplebusinessBody mass index030217 neurology & neurosurgeryestudios transversalesGlycaemic Controldescription
This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c= 53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-10-31 |