6533b82ffe1ef96bd1294695
RESEARCH PRODUCT
Asymmetric Synthesis of Monofluorinated 1-Amino-1,2-dihydronaphthalene and 1,3-Amino Alcohol Derivatives.
Günter HaufePablo BarrioRuben LazaroSantos FusteroDaniel M. SedgwickRaquel Románsubject
Reaction conditionschemistry.chemical_compound010405 organic chemistryStereochemistryChemistryOrganic ChemistryEnantioselective synthesisAlcoholPhysical and Theoretical Chemistry010402 general chemistry01 natural sciencesBiochemistry0104 chemical sciencesdescription
Enantioenriched 1-amino-4-fluoro-1,2-dihydronaphthalene derivatives are accessed via two complementary synthetic strategies. The careful optimization of the reaction conditions required for the elimination step in one route has allowed both the identification of an anchimerically assisted reaction pathway and, more importantly, access to a divergent reaction pathway toward fluorinated 1,3-amino alcohols from a common intermediate just by adjusting the number of equivalents of base used.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Organic letters |