Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes

6533b82ffe1ef96bd1294731

RESEARCH PRODUCT

Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes

Patricia Fernandez María José Alcaraz Maria Isabel Guillén Francisco Gomar

subject

Male Necrosis medicine.medical_treatment Biochemistry Gene Expression Regulation Enzymologic Chondrocyte chemistry.chemical_compound Chondrocytes Osteoarthritis medicine Humans Heme Aged Pharmacology Regulation of gene expression business.industry Cartilage Interleukin-17 Membrane Proteins Interleukin Interleukin-10 Cell biology Heme oxygenase medicine.anatomical_structure Cytokine chemistry Heme Oxygenase (Decyclizing)Immunology Cytokines Female medicine.symptom business Heme Oxygenase-1 Interleukin-1

description

Heme oxygenase-1 (HO-1) is implicated in the protection against tissue injury. We investigated the expression of this protein in cartilage sections and chondrocytes obtained from osteoarthritic patients. HO-1 was immunodetected in preparations from cartilage and also in chondrocytes cultured in the absence of stimulation. We found that HO-1 can be modulated by cytokines since the pro-inflammatory cytokines interleukin (IL)-1beta, IL-17 and tumour necrosis factor-alpha (TNF-alpha) down-regulated this protein, whereas the anti-inflammatory cytokine IL-10 exerted the opposite effect. Our results suggest a role for HO-1 as part of protective mechanisms against tissue injury in human cartilage.

year	journal	country	edition	language
2003-11-06	Biochemical Pharmacology

https://doi.org/10.1016/s0006-2952(03)00543-4

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