6533b82ffe1ef96bd12947b7

RESEARCH PRODUCT

Expression of Pre-S-Encoded Proteins in Sera of Individuals Chronically Infected with Hepatitis D Virus

K. H. Meyer Zum BüschenfeldeG. GerkenM.p. MannsB. MöllerGeorg HessWeber C

subject

Hepatitis B virusHepatitis b e antigenHepatitis B Surface AntigensvirusesGastroenterologyBiologymedicine.disease_causeHepatitis b surface antigenmedicine.diseaseVirologyHepatitis DHepatitis DViral Envelope ProteinsViral typeChronic DiseaseDNA ViralImmunologymedicineHumansHepatitis B e AntigensViral diseaseHepatitis D virusProtein PrecursorsDna viral

description

The sera of 16 individuals chronically infected with the hepatitis D virus were analyzed for hepatitis B virus (HBV) markers. The majority of these patients had a non-replicative form of viral type B hepatitis as indicated by negative tests for HBeAg and HBV-DNA. Pre-S-encoded proteins were detected in 13/16 sera. Sera that were negative for polymerized serum albumin did also not contain pre-S1-encoded proteins. The presence of pre-S-encoded proteins is probably predominantly associated with 22-nm HBsAg forms present in large amounts in sera of individuals with chronic type D hepatitis.

yearjournalcountryeditionlanguage
1988-01-01Digestion
https://doi.org/10.1159/000199643