6533b82ffe1ef96bd129481b

RESEARCH PRODUCT

Synthesis and antimicrobial screening of tetra Schiff bases of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene

Mustafa KatanEva RentschlerEmad YousifNadia SalihJumat SalimonAyad S. Hameed

subject

Chemistry(all)biologyChemistryStereochemistryAspergillus nigerBacillus cereus134-ThiadiazoleGeneral Chemistrybiology.organism_classificationAntimicrobialAntifungalAspergillus fumigatusAntibacterialStaphylococcus epidermidisProton NMRTetraTetra Schiff baseMicrococcus luteusNuclear chemistry

description

Abstract In the present study, novel tetra Schiff bases were synthesized by condensation of 1,2,4,5-tetra (5-amino-1,3,4-thiadiazole-2-yl)benzene with different aromatic aldehydes. The chemical structures were confirmed by means of IR, 1 H NMR, 13 C NMR, and elemental analysis. All compounds were screened for antibacterial ( Staphylococcus aureus ATCC-9144, Staphylococcus epidermidis ATCC-155, Micrococcus luteus ATCC-4698, Bacillus cereus ATCC-11778, Escherichia coli ATCC-25922, and Pseudomonas aeruginosa ATCC-2853) and antifungal ( Aspergillus niger ATCC-9029 and Aspergillus fumigatus ATCC-46645) activities by paper disc diffusion technique. The minimum inhibitory concentrations (MICs) of the compounds were also determined by agar streak dilution method. Among the synthesized compounds 1,2,4,5-tetra[5-(4-nitrobenzylideneamino)-1,3,4-thiadiazole-2-yl]benzene 7 was found to be the most potent antimicrobial activity with MICs of 3.4, 2.1, 1.2, 2.0, 3.1, 2.4, 1.1, and 1.7 μg/mL against the above mentioned respective strains.

yearjournalcountryeditionlanguage
2014-07-01Journal of Saudi Chemical Society
10.1016/j.jscs.2011.07.007http://dx.doi.org/10.1016/j.jscs.2011.07.007