6533b82ffe1ef96bd1294891

RESEARCH PRODUCT

Treatment guidelines of metastatic colorectal cancer in older patients from the French Society of Geriatric Oncology (SoFOG)

Gilles AlbrandTristan CudennecLeila Bengrine-lefevreCamille PetriAnne-marie BouvierEric FrancoisElena PaillaudJean-marc PhelipElisabeth CarolaBérengère CouturierFlorence Canoui-poitrinePhilippe CailletThomas Aparicio

subject

medicine.medical_specialtyBevacizumabColorectal cancermedicine.medical_treatment[SDV]Life Sciences [q-bio]Context (language use)Targeted therapyMetastasisMetastasisTargeted therapy03 medical and health scienceschemistry.chemical_compoundOlder patient0302 clinical medicineRegorafenibMedicineHumansChemotherapyNeoplasm MetastasisIntensive care medicineSocieties MedicalAgedNeoplasm StagingHepatologyPerformance statusbusiness.industryGastroenterologymedicine.diseaseCombined Modality TherapyColorectal cancer3. Good healthGeriatric oncologychemistry030220 oncology & carcinogenesisQuality of Life030211 gastroenterology & hepatologyFrancebusinessColorectal Neoplasmsmedicine.drug

description

International audience; Background: Several guidelines dedicated to metastatic colorectal cancer (mCRC) are available. Since 2013 no recent guidelines are specifically dedicated to older patients and based on a systematic review. Materials and methods: A multidisciplinary Task Force with digestive oncologists, geriatricians and methodologists from the SoFOG was formed in 2016 to update recommendations on medical treatment of mCRC based on a systematic review of publications from 2000 to 2018. Search strategy has followed a standardized protocol from the formulation of clinical questions and definition of a search algorithm to the selection of complete articles for recommendations. Results: The four selected key questions were: For which older patients with mCRC can we considered: (1) Any chemotherapy, (2) Mono or poly-chemotherapy, (3) Anti-angiogenic therapy, (4) Other targeted therapy. Main recommendations for older patients are: (1) Omission of chemotherapy should be discussed with a geriatrician for patients with severe comorbidities, advanced dementia, uncontrolled psychiatric disorder or severe loss of autonomy. (2) If tumor response is not the main aim, a mono-chemotherapy with 5-fluorouracil combined with bevacizumab is recommended as first-line. (3) For patients with symptoms related to metastases or with a planned metastasis ablation, a doublet chemotherapy combined with bevacizumab or anti-EGFR antibody in the context of a RAS wild type tumor is recommended as first-line. Preliminary data suggest that regorafenib may be used, in its registered indication, in patients under 80 with a performance status of 0 and no autonomy alterations and that trifluridine-tipiracil may be used with a tight supervising of hematological function.

10.1016/j.dld.2019.12.145https://hal.archives-ouvertes.fr/hal-03227853