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RESEARCH PRODUCT
Role of non-coding RNAs as biomarkers of deleterious cardiovascular effects in sepsis.
Alejandro Cardona-monzonísFederico V. PallardóFederico V. PallardóNieves CarbonellJosé Luis García-giménezElena Nacher-sendraJesús Beltrán-garcíaJesús Beltrán-garcíaFabian Sanchis-gomarRebeca Osca-verdegalCarl J. Laviesubject
Regulation of gene expressionbusiness.industryCardiomyopathyInflammationDiseaseRNA Circularmedicine.diseaseBioinformaticsRisk AssessmentSepsisMicroRNAsHeart Disease Risk FactorsSepsismicroRNAmedicineAnimalsHumansRNA Long NoncodingEpigeneticsmedicine.symptomCardiology and Cardiovascular MedicinebusinessCardiomyopathiesReprogrammingBiomarkersdescription
The mechanisms occurring during sepsis that produce an increased risk of cardiovascular (CV) disease (CVD) are poorly understood. Even less information exists regarding CV dysfunction as a complication of sepsis, particularly for sepsis-induced cardiomyopathy. However, recent research has demonstrated that non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in genetic reprogramming, gene regulation, and inflammation during the development of CVD. Here we describe experimental findings showing the importance of non-coding RNAs mediating relevant mechanisms underlying CV dysfunction after sepsis, so contributing to sepsis-induced cardiomyopathy. Importantly, non-coding RNAs are critical novel regulators of CVD risk factors. Thus, they are potential candidates to improve diagnostics and prognosis of sepsis-induced cardiomyopathy and other CVD events occurring after sepsis and set the basis to design novel therapeutic strategies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-09-01 | Progress in cardiovascular diseases |