Antikonvulsiva, 1. Mitt. Thiocarbamoylbutyroguanamine

6533b82ffe1ef96bd1295a03

RESEARCH PRODUCT

Antikonvulsiva, 1. Mitt. Thiocarbamoylbutyroguanamine

Alfred Kreutzberger M. Loch

subject

Acylation chemistry.chemical_compound Chemistry Stereochemistry Drug Discovery Isothiocyanate Mass spectrum Pharmaceutical Science Butyroguanamine Nuclear magnetic resonance spectroscopy Inhibitory effect

description

Durch Anlagerung von Butyroguanamin (1) an die Isothiocyanate 2a-c sind die Thiocarbamoylbutyroguanamine 3a-c zuganglich. Auf dem Wege der Acylierung von 3 sind unsymmetrisch substituierte Butyroguanamine 4 erhaltlich. Unter den neu entwickelten Verbindungen zeichnet sich insbesondere 3c durch antikonvulsive, fungizide und die Magensauresekretion hemmende Wirkungen aus. Anticonvulsivic Agents, I: Thiocarbamoylbutyroguanamines The thiocarbamoylbutyroguanamines 3a-c are accessible by addition of butyroguanamine (1) to the isothiocyanates 2a-c. Unsymmetrically substituted butyroguanamines 4 are obtainable by acylation of 3. Among the newly prepared compounds, 3c in particular exhibits anticonvulsivic and fungicidal activities and exerts an inhibitory effect on gastric juice secretion.

year	journal	country	edition	language
1986-01-01	Archiv der Pharmazie

https://doi.org/10.1002/ardp.19863190902

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