6533b82ffe1ef96bd1295a10

RESEARCH PRODUCT

4-Hydroxynonenal-Induced Relaxation of Human Mesenteric Arteries1

Pascual EmedinaM C MartinezMaría José Miquel RomeroSalvador LluchFrancisco J. RomeroFrancisco Bosch-morell

subject

medicine.medical_specialtyRelaxation (psychology)Endotheliummedicine.disease_causeBiochemistryVascular tone4-HydroxynonenalNitric oxideLipid peroxidationchemistry.chemical_compoundEndocrinologymedicine.anatomical_structurechemistryBiochemistryPhysiology (medical)Internal medicinemedicineMesenteric arteriesOxidative stress

description

The effect of 4-hydroxynonenal (4-HNE), a circulating lipid peroxidation product, on the vascular tone of human mesenteric arteries is studied. 4-HNE promotes relaxation of human mesenteric arterial rings in a concentration-dependent manner. Removal of the endothelium or treatment with N(G)-nitro-L-arginine methyl ester hydrochloride (L-NAME; 10(-4) M) partially prevented 4-HNE-induced relaxation, thus suggesting the intervention of nitric oxide from endothelial origin in the vascular effects of 4-HNE.

yearjournalcountryeditionlanguage
1997-01-01Free Radical Biology and Medicine
https://doi.org/10.1016/s0891-5849(97)00119-6