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RESEARCH PRODUCT
Stem cells, cancer stem-like cells, and natural products.
Thomas EfferthThomas A. Efferthsubject
Pluripotent Stem CellsPathologymedicine.medical_specialtyCell SurvivalStem cell theory of agingPharmaceutical ScienceClinical uses of mesenchymal stem cellsTretinoinBiologyAnalytical ChemistryCancer stem cellNeoplasmsDrug DiscoverymedicineHumansCell LineageProgenitor cellEmbryonic Stem CellsStem cell transplantation for articular cartilage repairCell ProliferationPharmacologyBiological ProductsOrganic ChemistryCell DifferentiationCell Cycle CheckpointsAntineoplastic Agents PhytogenicCell biologyComplementary and alternative medicineAmniotic epithelial cellsNeoplastic Stem CellsMolecular MedicineStem cellAdult stem cellSignal Transductiondescription
Somatic stem cells can be found in many rapidly regenerating tissues, e.g., the skin, gastrointestinal mucosa, and hematopoietic system, but are also present at low numbers in non-regenerative organs such as the heart and brain. In these organs, somatic stem cells aid in normal tissue homeostasis and repair after injury as well as self-renewal and the generation of specific progenitor cells during differentiation. Cancer stem-like cells are a small subpopulation of self-renewing cells that are able to proliferate upon appropriate stimulation and differentiate into heterogeneous lineages in tumors. Modulation of the behavior of normal tissue stem cells and cancer stem-like cells is an emerging and thriving new field of research. The present review gives an overview of the state-of-the-art findings and highlights perspectives for future scientific developments and clinical application.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-05-09 | Planta medica |