6533b82ffe1ef96bd1295be2

RESEARCH PRODUCT

Polymorphisms of Pro-Inflammatory IL-6 and IL-1β Cytokines in Ascending Aortic Aneurysms as Genetic Modifiers and Predictive and Prognostic Biomarkers

Valeria CancilaDomenico LioCalogera PisanoGiacomo FratiRosa Maria GiarratanaGiovanni RuvoloCarmela Rita BalistreriVincenzo MarinelloLetizia Scola

subject

Male0301 basic medicinemedicine.medical_specialtyInterleukin-1betamedial cell apoptosisSingle-nucleotide polymorphism030204 cardiovascular system & hematologyrs16944MicrobiologyPolymorphism Single NucleotideBiochemistryGastroenterologyArticleProinflammatory cytokinePathogenesis03 medical and health sciences0302 clinical medicineAneurysmInternal medicineGenotypeelastic fragmentationmedicinetelomere lengthHumansInterleukin 6thoracic ascending aortic aneurysmsMolecular BiologyAgedAortic Aneurysm ThoracicbiologyInterleukin-6business.industryMMP9Prognosismedicine.diseasers1800795QR1-502Settore MED/23030104 developmental biologyproinflammatory cytokinescystic medial changesbiology.proteinCytokinesBiomarker (medicine)FemaleTumor necrosis factor alphaInflammation MediatorsbusinessBiomarkers

description

Background: Previous studies have demonstrated that polymorphisms involved in immune genes can affect the risk, pathogenesis, and outcome of thoracic ascending aortic aneurysms (TAAA). Here, we explored the potential associations of five functional promoter polymorphisms in interleukin-6 (IL-6), IL-1B, IL-1A, IL-18, and Tumor necrosis factor (TNF)A genes with TAAA. Methods: 144 TAAA patients and 150 age/gender matched controls were typed using KASPar assays. Effects on telomere length and levels of TAAA related histopathological and serological markers were analyzed. Results: Significant associations with TAAA risk were obtained for IL-6 rs1800795G&gt

yearjournalcountryeditionlanguage
2021-06-25Biomolecules
10.3390/biom11070943http://dx.doi.org/10.3390/biom11070943