Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy

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RESEARCH PRODUCT

Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy

Ana M. Lendínez-ramírez Maximiliano Ruiz-galdón Maximiliano Ruiz-galdón A.r. Palomares Nicolás Garrido Francisco Martínez Armando Reyes-engel Beatriz Pérez-nevot Miriam Cortés-rodríguez

subject

Adult medicine.medical_specialty medicine.medical_treatment Early Pregnancy Loss Fertilization in Vitro Polymorphism Single Nucleotide Andrology Gene Frequency Pregnancy Risk Factors Internal medicine Genotype Odds Ratio medicine Humans Embryo Implantation Serotonin transporter Serotonin Plasma Membrane Transport Proteins Analysis of Variance Pregnancy Chi-Square Distribution In vitro fertilisation Oocyte Donation biology Haplotype Obstetrics and Gynecology Embryo Transfer medicine.disease Embryo transfer Abortion Spontaneous Pregnancy rate Logistic Models Phenotype Treatment Outcome Endocrinology Haplotypes Reproductive Medicine Case-Control Studies Receptor Serotonin 5-HT1A biology.protein Female

description

Objective To explore whether serotonin-related gene polymorphisms influence clinical outcomes of IVF treatment in recipients using donated oocytes. Design Nested case-control study. Setting University-affiliated infertility clinic. Patient(s) Two hundred forty-five women undergoing IVF treatment with donated oocytes. Intervention(s) None. Main Outcome Measure(s) Genotype and haplotype analysis of the serotonin transporter-linked polymorphic region (5-HTTLPR), rs1800532, rs6295, rs6313, and rs3813929, between recipients grouped according to the results of the oocyte donation for IVF treatment. Result(s) No differences were found between genotype distribution of the tryptophan hydroxylase 1, serotonin receptor 2A, and serotonin receptor 2C polymorphisms. Recipients carrying the LL genotype for 5-HTTLPR had lower clinical pregnancy rates (PR) and higher biochemical pregnancy loss (BPL) events. Lower implantation rates were found in CC carriers for 5-HT1A.rs6295 who also presented higher BPL rates. A lower incidence of clinical pregnancy was observed for LC haplotypes, corresponding to an increase in BPL rates. Conclusion(s) A strong association was found between early pregnancy loss and recipients carrying the 5-HTTLPR and rs6295 genetic variants. Identifying biological processes involving serotonin and embryo implantation may help to understand the dynamics of the maternal–embryo dialogue.

year	journal	country	edition	language
2012-10-11	Fertility and Sterility

https://doi.org/10.1016/j.fertnstert.2013.02.026