6533b82ffe1ef96bd1295dbe
RESEARCH PRODUCT
Monoclonal antibodies against components of the classical pathway of complement.
Hans-peter HeinzMichael Loossubject
medicine.drug_classComplement Activating EnzymesImmunologyComplement C3-C5 ConvertasesComplement C3-C5 ConvertasesMonoclonal antibodyEpitopeClassical complement pathwayEpitopesComplement C1medicineComplement Pathway ClassicalComplement C1qComplement ActivationComplement component 2biologyChemistryComplement C1qAntibodies MonoclonalComplement C4HematologyComplement System ProteinsComplement C2Complement systemBiochemistrybiology.proteinAntibodydescription
Activation of the classical pathway of complement involves several binding and enzymatic cleavage processes. Binding and enzymatic activation results in the appearance of new structures in the individual components. This report describes the different activation steps for C1q, C1r, C1s, C4 and C2 and summarizes monoclonal antibodies reported so far which recognize either conserved epitopes or activation-dependent epitopes with particular emphasis on neoepitopes occurring during the activation cascade.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-01-01 | Complement and inflammation |