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RESEARCH PRODUCT
Hemorheological abnormalities in human arterial hypertension
Rosalia Lo PrestiGregorio CaimiEugenia Hoppssubject
erythrocyte deformabilitymedicine.medical_specialtySettore MED/09 - Medicina InternaRed Cellbusiness.industryerythrocyte membraneBlood viscosityessential hypertensionessential hypertension blood viscosity erythrocyte deformabilityCondensed Matter PhysicsEssential hypertensionmedicine.diseaseLeft ventricular hypertrophyPathophysiologyErythrocyte membraneInternal medicinePathophysiology of hypertensionblood viscositymedicineCardiologyErythrocyte deformabilityGeneral Materials Sciencebusinessdescription
Blood rheology is impaired in hypertensive patients. The alteration involves blood and plasma viscosity, and the erythrocyte behaviour is often abnormal. The hemorheological pattern appears to be related to some pathophysiological mechanisms of hypertension and to organ damage, in particular left ventricular hypertrophy and myocardial ischemia. Abnormalities have been observed in erythrocyte membrane fluidity, explored by fluorescence spectroscopy and electron spin resonance. This may be relevant for red cell flow in microvessels and oxygen delivery to tissues. Although blood viscosity is not a direct target of antihypertensive therapy, the rheological properties of blood play a role in the pathophysiology of arterial hypertension and its vascular complications.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-05-01 | Korea-Australia Rheology Journal |