First unequivocal synthesis of dissymmetrical trans N,N′-difunctionalized 1,4,8,11-tetraazacyclotetradecane

6533b82ffe1ef96bd12963e2

RESEARCH PRODUCT

First unequivocal synthesis of dissymmetrical trans N,N′-difunctionalized 1,4,8,11-tetraazacyclotetradecane

Guy Royal Roger Guilard Christophe Bucher Jean-michel Barbe

subject

chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Cyclam Biochemistry

description

Abstract The first unequivocal synthesis of disymmetrical trans N,N′-difunctionalized tetraazamacrocycles in cyclam series is reported. This convenient four-step method can be used for the synthesis of various trans N,N′-difunctionalized tetraazamacrocycles bearing two different pendant donor arms.

year	journal	country	edition	language
1999-03-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(99)00190-2

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