Preparation and Structures of Isoindolone- or Pyrimidone-Condensed Heterocycles Containing a Hydroxy Group on a Cyclohexane or Norbornane Moiety

6533b82ffe1ef96bd1296546

RESEARCH PRODUCT

Preparation and Structures of Isoindolone- or Pyrimidone-Condensed Heterocycles Containing a Hydroxy Group on a Cyclohexane or Norbornane Moiety

Reijo Sillanpää Géza Stájer Ferenc Miklós Antal Csámpai Pál Sohár

subject

chemistry.chemical_classification Cyclohexane Organic Chemistry Carbon-13 NMR Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Thiazepine Moiety Pyrimidone Norbornane Isoindole Lactone

description

With DL-valinol, 3-amino-1-propanol and o-aminothiophenol, aroyl(bi/tri)cyclic lactones 1 and 2 were cy- clized to isoindole- 4-6, 8, 9, pyrimidinone- 10 or thiazepine- 7 condensed heterocycles. The ketal lactone 3 furnished the benzthiazoloisoindole 9 and mixtures of epimeric hydroxyphthalazinoquinazolinones 11 and 12. The structures were es- tablished by means of 1 H and 13 C NMR spectroscopy and in some cases by X-ray crystallography.

year	journal	country	edition	language
2009-04-01	Letters in Organic Chemistry

https://doi.org/10.2174/157017809787893136

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