Search results for "Norbornane"
showing 8 items of 8 documents
Effects of thrombin and of the phospholipase C inhibitor, D609, on the vascularity of the chick chorioallantoic membrane.
2000
Abstract Microvascular corrosion casting was used to assess the effects of thrombin and D609, a phospholipase C inhibitor, on the vascularity of the chick embryo chorioallantoic membrane (CAM). Discs containing vehicle, thrombin or D609 were placed on the CAM of fertilized white Leghorn eggs on Day 9 of gestation and vascularity was assessed on Day 11. Thrombin caused significant increases in the numbers (43%), diameters (5%) and lengths (17%), of both pre- and postcapillaries (first-order vessels by centripetal ordering). Conversely, D609 caused a decrease in the numbers (27%), lengths (12%) and diameters (8%) of first-order vessels. D609 decreased the total vascular volume of first- to th…
Pauson-Khand reaction of internal dissymmetric trifluoromethyl alkynes. Influence of the alkene on the regioselectivity.
2014
Abstract: The scope of the Pauson-Khand reaction (PKR) of internal trifluoromethyl alkynes, previously described with norbornadiene, is expanded to norbornene and ethylene. A thorough structural analysis of the resulting PK adducts has been carried out to unveil that α-trifluoromethylcyclopentenones are preferred in all cases, independently of the electronic properties of the alkyne. The regioselectivity observed with norbornadiene and ethylene is higher than in the case of norbornene.
Metabolism of polychlorinated norbornenes by Clostridium butyricum.
1972
STUDIES of the metabolism of cyclodien-insecticides, such as dieldrin, endrin, endosulphan, have revealed valuable information about their fate in the ecosystem1. With all metabolites identified so far, however, the hexachlorinated norbornene moiety remains unchanged2,3. Only from photodieldrin, a cage-like derivative of dieldrin, have dechlorinated metabolites been reported4,5.
Development and optimization of gas chromatography coupled to high resolution mass spectrometry based method for the sensitive determination of Dechl…
2017
An analytical method has been developed for the trace determination of 10 dechlorane-related compounds (DRCs) in food products by gas chromatography - high resolution mass spectrometry (GC-HRMS). The highest sensitivity of this instrumental analysis method was achieved by selection of the GC column type, optimization of the heated zones within the instrument, and adjusting the electron impact energy. The efficiency of solid phase extraction as clean-up procedure was also optimized. Two different types of cartridges - neutral silica gel and Florisil®, as well as seven organic solvents or their mixtures - n-hexane, cyclohexane, acetone, toluene, n-hexane/ethyl acetate, n-hexane/acetone, and n…
Electronic structure of terpene derivatives
1998
Abstract He I photoelectron spectra of terpene derivatives and their preparative intermediates have been measured. The changes of the ionization potentials are discussed in relation to the corresponding variations of the electronic structure. Especially, the effect of methyl and oxygen substitution has been studied.
Pentakis(dimethylzinn)diphosphid, struktur und kernresonanzspektren eines zinnreichen bicyclus
1979
Abstract Dehydrogenation of dimethylstannane combined with the hydrostannolysis of white phosphorus yields pentakis(dimethyltin) diphosphide, a tin-rich heterocyclic compound, which has the highly symmetric, bicyclic molecular structure of norbornane. Using the X-ray structure data the magnetic resonance spectra are discussed.
Preparation and Structures of Isoindolone- or Pyrimidone-Condensed Heterocycles Containing a Hydroxy Group on a Cyclohexane or Norbornane Moiety
2009
With DL-valinol, 3-amino-1-propanol and o-aminothiophenol, aroyl(bi/tri)cyclic lactones 1 and 2 were cy- clized to isoindole- 4-6, 8, 9, pyrimidinone- 10 or thiazepine- 7 condensed heterocycles. The ketal lactone 3 furnished the benzthiazoloisoindole 9 and mixtures of epimeric hydroxyphthalazinoquinazolinones 11 and 12. The structures were es- tablished by means of 1 H and 13 C NMR spectroscopy and in some cases by X-ray crystallography.
Indoloquinolines, Indolobenzoxazines and Quinazolophthalazines Prepared from Norbornane/eneamino Acids and Hydrazides
2005
The reactions of di-endo- and di-exo-aminonorbornane/enecarboxylic acids 1–4 with ethyl 2-(2-oxocyclohexyl)acetate afforded methanoindoloquinolines 5, 6, 8, and 9, the oxo ester participating as a two-membered sp2 building block. In the cases of di-exo- and di-endo-aminonorbornenecarboxylic acids 2 and 4, methanoindolobenzoxazinediones 7 and 10 were also formed; compound 7 was also isolated from the mother liquor of 10. The reactions of ethyl 2-(2-oxocyclohexyl)acetate with aminonorbornane/enecarbohydrazides 11–14 result in the methanoquinazolophthalazines 15–18. The structures of the compounds were elucidated by NMR spectroscopy, and for 6, 7, 8, and 10 also by X-ray crystallography. (© Wi…