6533b830fe1ef96bd1296570
RESEARCH PRODUCT
Synthesis of tritium labeled (�)-1-[2(triphenylmethoxy)ethyl]-3-piperidinecarboxylic acid: a possible compound to determine the efficacy of potential GABA transporter substancesin vitro
Frank RöschHartmut LüddensWilhelm HamkensRalf Schirrmachersubject
LigandStereochemistryOrganic ChemistryEtherBiochemistryChemical synthesisMedicinal chemistryLithium hydroxideAnalytical Chemistrychemistry.chemical_compoundHydrolysischemistryYield (chemistry)Drug DiscoveryRadiology Nuclear Medicine and imagingTritiumSpecific activitySpectroscopydescription
(±)-1-[2-(Triphenyl[ 3 H]methoxy)ethyl]-3-piperidinecarboxylic acid ([ 3 H]SNAP-5114) with a specific activity of 40 Ci/mmol was prepared in a two step synthesis starting from ethyl (2-(4-hydroxyphenyl)bis(4-methoxyphenyl)methoxy)-ethyl)piperidine-3-carboxylate and [ 3 H]methyliodide with subsequent hydrolysis of the resulting ester with lithium hydroxide to yield the desired [ 3 H]SNAP-5114.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-01-01 | Journal of Labelled Compounds and Radiopharmaceuticals |