6533b830fe1ef96bd12965a3
RESEARCH PRODUCT
Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane
Martin HeineLaura C. AndreaeRuth D. TaylorNigel J. Emptagesubject
Neuroscience ; Optical Materials ; Molecular Neuroscienceanimal structuresHippocampal formationArticle03 medical and health sciences0302 clinical medicinePremovement neuronal activityEphB2 Receptorslcsh:ScienceCytoskeletonReceptor030304 developmental biology0303 health sciencesOptical MaterialsChemistrymusculoskeletal neural and ocular physiologyVesiclefungiTransmembrane protein3. Good healthMembranenervous systemBiophysicslcsh:QMolecular Neuroscience030217 neurology & neurosurgeryNeurosciencedescription
Summary Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a subpopulation of neuronal EphB2 receptors that exhibit directed motion between synapses within the plasma membrane itself. This receptor movement occurs independently of the cytoskeleton but is dependent on cholesterol and is regulated by neuronal activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 |