6533b830fe1ef96bd129682b

RESEARCH PRODUCT

Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System

Marta Orts-arroyoJosé Martínez-lilloIsabel Castro

subject

Models MolecularPurinelcsh:BiotechnologyClinical BiochemistryMolecular Conformationchemistry.chemical_elementinosine02 engineering and technology010402 general chemistry01 natural sciencesArticleHydrolysischemistry.chemical_compoundX-Ray DiffractionLimit of Detectionlcsh:TP248.13-248.65medicineMolecule6-mercaptopurinerutheniumInosinePurine metabolismHypoxanthineazathioprineHydrolysisGeneral Medicine021001 nanoscience & nanotechnologyCombinatorial chemistry0104 chemical sciencesRutheniumchemistryPurineshypoxanthineMicroscopy Electron ScanningbiomarkerCyclic voltammetry0210 nano-technologyImmunosuppressive Agentsmedicine.drug

description

Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of disease states. Consequently, the discovery and development of systems suitable for the detection of hypoxanthine is pretty appealing in this research field. Thus, we have obtained a stable diruthenium (III) compound in its dehydrated and hydrated forms with formula [{Ru(&micro

https://doi.org/10.3390/bios11010019