6533b830fe1ef96bd1297043
RESEARCH PRODUCT
Polyhydroxylated indolizidine alkaloids-synthesis of dideoxycastanospermine
Ari M. P. KoskinenAri M. P. KoskinenOili A. KallatsaMaija Nissinensubject
Intramolecular reactionStereochemistryOrganic ChemistryIndolizidineBiochemistryChemical synthesischemistry.chemical_compoundCastanosperminechemistryDihydroxylationIntramolecular forceDrug DiscoveryChemical reductionOrganic chemistryProtecting groupdescription
The key transformation developed in this work is the anti-Kishi selective dihydroxylation, which proceeds by way of intramolecular participation of the nitrogen protecting group to furnish the desired stereochemistry required for castanospermine like structures. In this paper, we completed a first syn-thesis of a novel dideoxycastanospermine 6. Peer reviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-11-01 |