6533b830fe1ef96bd12971f7

RESEARCH PRODUCT

An electrophysiological study of the ontogenesis of adenosine receptors in the CA1 area of rat hippocampus

Caterina PsarropoulouGeorge K. KostopoulosHelmut L. Haas

subject

Malemedicine.medical_specialtyAdenosinemedicine.drug_classAction PotentialsHippocampusBiologyHippocampal formationHippocampuschemistry.chemical_compoundAdenosine A1 receptorDevelopmental NeuroscienceThioinosineCaffeineInternal medicinemedicineAnimalsmusculoskeletal neural and ocular physiologyReceptors PurinergicRats Inbred StrainsReceptor antagonistAdenosineAdenosine receptorRatsEndocrinologynervous systemchemistryExcitatory postsynaptic potentialFemaleCaffeineDevelopmental Biologymedicine.drug

description

Abstract The depressant effect of adenosine (Ad) was studied electrophysiologically in hippocampal slices from 5-, 10-, 15-, 20-, 30- and 120-day-old rats. Ad (10μM) depressed the field EPSP in CA1 to the same extent in all age groups. Caffeine (Caf), an Ad receptor antagonist, enhanced and nitrobenzylthioinosine (NBI), an Ad uptake blocker, depressed the field EPSP. Both these effects were, however, less prominent in slices from younger animals, a finding consistent with lower extracellular levels of endogenous Ad in neonatal rats.

yearjournalcountryeditionlanguage
1990-08-01Developmental Brain Research
https://doi.org/10.1016/0165-3806(90)90116-g