0000000000761553

AUTHOR

Caterina Psarropoulou

showing 2 related works from this author

An electrophysiological study of the ontogenesis of adenosine receptors in the CA1 area of rat hippocampus

1990

Abstract The depressant effect of adenosine (Ad) was studied electrophysiologically in hippocampal slices from 5-, 10-, 15-, 20-, 30- and 120-day-old rats. Ad (10μM) depressed the field EPSP in CA1 to the same extent in all age groups. Caffeine (Caf), an Ad receptor antagonist, enhanced and nitrobenzylthioinosine (NBI), an Ad uptake blocker, depressed the field EPSP. Both these effects were, however, less prominent in slices from younger animals, a finding consistent with lower extracellular levels of endogenous Ad in neonatal rats.

Malemedicine.medical_specialtyAdenosinemedicine.drug_classAction PotentialsHippocampusBiologyHippocampal formationHippocampuschemistry.chemical_compoundAdenosine A1 receptorDevelopmental NeuroscienceThioinosineCaffeineInternal medicinemedicineAnimalsmusculoskeletal neural and ocular physiologyReceptors PurinergicRats Inbred StrainsReceptor antagonistAdenosineAdenosine receptorRatsEndocrinologynervous systemchemistryExcitatory postsynaptic potentialFemaleCaffeineDevelopmental Biologymedicine.drugDevelopmental Brain Research
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Action of anticonvulsants on hippocampal slices in Mg-free medium

1989

The effects of six prototype anticonvulsant drugs were investigated on epileptiform field potential discharges evoked in hippocampal slices of rats by removing magnesium ions from the perfusion fluid in order to reveal a possible interaction with N-methyl-D-aspartate (NMDA) receptor activation. All drugs reduced the multiple discharges with the following order of potency: midazolam greater than carbamazepine = phenytoin = phenobarbital greater than ethosuximide = valproate. They had a stronger depressant effect on the later population spikes but none of them abolished the epileptiform discharge. These effects can be explained by known mechanisms of action of the anticonvulsants tested and l…

N-Methylaspartatemedicine.medical_treatmentPopulationPyramidal TractsIn Vitro TechniquesPharmacologyHippocampusReceptors N-Methyl-D-AspartatemedicineAnimalsMagnesiumeducationMagnesium ionPharmacologyAspartic Acideducation.field_of_studyEpilepsyDose-Response Relationship DrugChemistryElectroencephalographyRats Inbred StrainsGeneral MedicineCarbamazepineElectric StimulationRatsReceptors NeurotransmitterPerfusionEthosuximideAnticonvulsantnervous systemMechanism of actionNMDA receptorAnticonvulsantsPhenobarbitalmedicine.symptommedicine.drugNaunyn-Schmiedeberg's Archives of Pharmacology
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