6533b830fe1ef96bd1297203
RESEARCH PRODUCT
The mitochondrial‐derived peptide MOTS ‐c: a player in exceptional longevity?
Nobuyoshi HiroseHirofumi ZempoNoriyuki FukuRafael AlisAlejandro LuciaYasumichi AraiHelios Pareja-galeanosubject
Asian Continental Ancestry GroupAgingMitochondrial DNAMitochondrial-Derived Peptide MOTS-cBiologíamedia_common.quotation_subjectLongevityMolecular biology of agingmitochondrial DNAGenética humanaMitochondrionBiologyDNA MitochondrialPolymorphism Single Nucleotidelongevity geneOpen Reading FramesAsian PeopleJapanCentenariansHumansmolecular biology of agingBiología humanaHumaninmedia_commonGeneticsBiología molecularGenMitochondrial DNA abnormalitiesLongevityCell Biologylongevity regulationLongevity geneMitochondrial DNAmitochondrial DNA abnormalitiesMitochondriaLongevity regulationOpen reading frameRNA RibosomalCommentaryAsian populationcentenariansPeptidesdescription
Mitochondrial-derived peptides (MDP) are encoded by functional short open reading frames in the mitochondrial DNA (mtDNA). These include humanin, and the recently discovered mitochondrial open reading frame of the 12S rRNA-c (MOTS-c). Although more research is needed, we suggest that the m.1382A>C polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, may be among the putative biological mechanisms explaining the high longevity of Japanese people. 5.760 JCR (2015) Q1, 36/187 Cell biology, 3/49 Geriatrics & gerontology UEM
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | Aging Cell |