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RESEARCH PRODUCT
Collective Viral Spread Mediated by Virion Aggregates Promotes the Evolution of Defective Interfering Particles
Iván Andreu-morenoRafael Sanjuánsubject
Cell typevirusesGene ExpressionEcological and Evolutionary ScienceGenome ViralBiologyVirus ReplicationMicrobiologyDeep sequencingVirusCell Linedefective interfering particles03 medical and health sciencesMultiplicity of infectionGenes ReporterVirologyAnimalsHumansexperimental evolutioncollective infectious unitssocial evolution030304 developmental biologyInfectivity0303 health sciencesExperimental evolution030306 microbiologyVirionDefective VirusesVesiculovirusbiology.organism_classificationBiological EvolutionVirologyQR1-5023. Good healthVirus DiseasesVesicular stomatitis virusBiological dispersalGenetic Fitnessvesicular stomatitis virusResearch Articledescription
Recent insights have revealed that viruses use a highly diverse set of strategies to release multiple viral genomes into the same target cells, allowing the emergence of beneficial, but also detrimental, interactions among viruses inside infected cells. This has prompted interest among microbial ecologists and evolutionary biologists in studying how collective dispersal impacts the outcome of viral infections. Here, we have used vesicular stomatitis virus as a model system to study the evolutionary implications of collective dissemination mediated by viral aggregates, since this virus can spontaneously aggregate in the presence of saliva. We find that saliva-driven aggregation has a dual effect on viral fitness; whereas aggregation tends to increase infectivity in the very short term, virion aggregates are highly susceptible to invasion by noncooperative defective variants after a few viral generations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 | mBio |