6533b830fe1ef96bd12972f5

RESEARCH PRODUCT

Oxidative DNA cleavage induced by an iron(III) flavonoid complex: synthesis, crystal structure and characterization of chlorobis(flavonolato)(methanol) iron(III) complex.

Gloria AlzuetJoaquín BorrásJosé RealL. PerellóJose Montejo-bernardoSantiago García-grandaMarta González-álvarezFátima Ben Allal El Amrani

subject

Models MolecularSpectrophotometry InfraredCrystal structurePhotochemistryCrystallography X-RayBiochemistryFerric Compoundslaw.inventionInorganic ChemistryMetalchemistry.chemical_compoundParamagnetismlawMoleculeElectron paramagnetic resonanceHydrogen peroxideBond cleavageMolecular StructureChemistryElectron Spin Resonance SpectroscopyDNAResonance (chemistry)CrystallographyOxidative Stressvisual_artvisual_art.visual_art_mediumSpectrophotometry Ultraviolet

description

A flavonol iron(III) complex, [Fe(flavonolato)(2)Cl(MeOH)], has been prepared. The compound has been characterized by X-ray crystallography, spectroscopy, magnetism and electronic paramagnetic resonance (EPR) at X- and Q-band. The geometrical environment around the metal is best described as rhombic distorted octahedral. This distortion has also been inferred from the magnetic measurements and from the EPR spectra at different temperatures, E/D(rhombicity parameter) approximately 0.06. The DNA cleavage activity of the iron(III) complex with and without ascorbate/hydrogen peroxide is reported. Mechanisms of the oxidative cleavage have been proposed when DNA strand scission is performed both with and without ascorbate/hydrogen peroxide activation.

yearjournalcountryeditionlanguage
2006-07-01Journal of inorganic biochemistry
10.1016/j.jinorgbio.2006.01.036https://pubmed.ncbi.nlm.nih.gov/16527356