Topotecan (T) ± sorafenib (S) in platinum-resistant ovarian cancer (PROC): A double-blind placebo-controlled randomized NOGGO–AGO intergroup Trial—TRIAS.

6533b830fe1ef96bd12979da

RESEARCH PRODUCT

Topotecan (T) ± sorafenib (S) in platinum-resistant ovarian cancer (PROC): A double-blind placebo-controlled randomized NOGGO–AGO intergroup Trial—TRIAS.

Hans-joachim Lueck Radoslav Chekerov Sven Mahner Jochem Potenberg Felix Hilpert Philipp Harter Susanne Markmann Petra Krabisch Marcus Schmidt Andreas Du Bois Rolf Richter Peter Klare Claudius Fridrich Isolde Groell Tanja Neunhoeffer Gabriele Doering Nikolaus De Gregorio Ralf Lorenz Jalid Sehouli Antje Belau

subject

Sorafenib Oncology Cancer Research medicine.medical_specialty 030219 obstetrics & reproductive medicine endocrine system diseases medicine.drug_class business.industry Placebo medicine.disease female genital diseases and pregnancy complications Double blind 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Internal medicine Toxicity medicine Topotecan business Ovarian cancer Topoisomerase inhibitor medicine.drug Platinum resistant

description

5522Background: Sorafenib (S), a multi TK-inhibitor in combination with topotecan (T), a topoisomerase inhibitor showed preclinical synergistic effects in ovarian cancer but critical toxicity. To a...

year	journal	country	edition	language
2016-05-20	Journal of Clinical Oncology

https://doi.org/10.1200/jco.2016.34.15_suppl.5522

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