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RESEARCH PRODUCT
Electrical Impedance, ICP and Histology in Rats with Sagittal Sinus Occlusion
Oliver KempskiAlexander BaethmannK. FrerichsLudwig SchürerA. Rüthersubject
medicine.medical_specialtyNeurologybusiness.industryHistologymedicine.diseaseThrombosisPathophysiologySagittal SinusInternal medicineOcclusionmedicineCardiologybusinessIntracranial pressureSuperior sagittal sinusdescription
The diversity of clinical symptoms developing after thrombosis of the cerebral superior sagittal sinus is not well understood [2, 4], This is largely related to our ignorance of the underlying pathophysiology. An improvement in the pathophysiological understanding can be expected by experimental studies. Although animal models are available fot that purpose they are, however, in short supply. A few years ago, our laboratory in collaboration with the department of neurology at the University of Munich made another attempt to establish a reproducible experimental model for the induction of thrombosis of the superior sagittal sinus in rats. In the present studies this model has been used to evaluate ischemic cell swelling, intracranial pressure and extension of venous infarction within the first 24 hours after induction of thrombosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 |