6533b830fe1ef96bd12979e4
RESEARCH PRODUCT
Cross-Metathesis/Intramolecular (Hetero-)Michael Addition: A Convenient Sequence for the Generation of Carbo- and Heterocycles
Javier MiróMaría Sánchez-rosellóCarlos Del Pozosubject
010405 organic chemistryStereochemistryOrganic Chemistrychemistry.chemical_element010402 general chemistryMetathesis01 natural sciencesCatalysisDomino0104 chemical sciencesRutheniumchemistry.chemical_compoundchemistryNucleophileIntramolecular forceSalt metathesis reactionMichael reactionCarbenedescription
The high stability and functional group compatibility of ruthenium carbene complexes confer them a great ability to catalyze domino processes. For this reason, the combination of metathesis reactions with additional transformations in a domino fashion has been exploited extensively, with the result of expanding the utility of ruthenium carbene complexes beyond that of just olefin metathesis. Among those domino processes, it is worth mentioning the sequence of cross-metathesis/intramolecular Michael addition, which allows for the generation of a wide variety of carbo- and heterocycles in a very simple manner, taking advantage of the benefits of domino reactions. Carbon-, oxygen- and nitrogen-centered nucleophiles are good partners in this protocol, the versatility of which has been illustrated with the synthesis of several biologically important compounds.1 Introduction2 Cross Metathesis/Intramolecular Aza-Michael Addition Sequences3 Cross Metathesis/Intramolecular Oxa-Michael Addition Sequences4 Cross Metathesis/Intramolecular Michael Addition Sequences5 Conclusions and Outlook
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-05-04 | Synthesis |