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RESEARCH PRODUCT
The Complement System: Activation and Control
Michael Loossubject
biologyC4b-binding proteinChemistrychemical and pharmacologic phenomenaBlood proteinsComplement systemC1-inhibitorClassical complement pathwayBiochemistryImmunologybiology.proteinAlternative complement pathwayLysine carboxypeptidaseComplement membrane attack complexdescription
One of the hallmarks of immunology has been analysis and characterization of the C system in biological fluids. It is composed of 11 proteins of the “classical” pathway:1 C1q, C1r, C1s, C4, C2, C3, C5, C6, C7, C8, and C9. There are three proteins of the “alternative” pathway (IUIS-WHO Nomenclature Committee 1981) B, D, and P. Finally, there are four control proteins: C1 inhibitor (Cl¯ INH) and C4b binding protein (C4b-bp) for the classical pathway, I (C3b inactivator or C3b INA) and H (β1 or C3b INA accelerator) for the alternative pathway, and anaphylatoxin inactivator. Due to the dramatic advances in protein chemistry, these 19 distinct serum proteins have been highly purified and characterized physiochemically (Table 1).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-01-01 |